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• FLUID IN KNEE PAIN TRIAL

“The amniotic suspension allograft injections are also a good option for older patients as well. Less is often more when it comes to treating these athletes because it is harder to get back to sport after surgery.” If there is a truly mechanical problem, then surgery is indicated, but many athletes just have pain and inflammation. He added, “We use a lot of injections with injured athletes. This balance between movement and rest can help you get back on track faster. If you’re feeling fine, try walking or doing some of the knee exercises below. “The amniotic fluid and membrane injection showed the best results because there are a lot of anti-inflammatory substances in amniotic membrane and it is the inflammation and swelling that really hurts.” ( 1) It’s suggested to let the pain and swelling levels guide you on how much you can move. OMERACT-OARSI responder rates for amniotic suspension allograft, HA, and saline groups were 69.1, 39.1 and 42.6%, respectively ( p = 0.0007).Īndreas Gomoll, M.D., a sports medicine and orthopedic surgeon at the Hospital for Special Surgery summarized the results of the study to OTW. They included 13.2% in the amniotic suspension allograft group, 68.8% in the HA group and 75% in the saline group.Īccording to the data collected, patients receiving ASA demonstrated greater improvements in overall pain (VAS), KOOS pain, and KOOS-activities of daily living scores compared to those in the (HA) group at 6 months and in both groups at 6 months. Any patient who reported unacceptable pain at 3 months were considered treatment failures and removed from the study. Primary endpoints included changes from baseline of patient-reported outcomes (PROs)-EQ-5D-5L, Knee Osteoarthritis Outcome Score (KOOS), visual analog scale (VAS), Tegner, and Single Assessment Numerical Evaluation (SANE). Two hundred subjects were randomized 1:1:1 to ASA, HA, or saline.

FLUID IN KNEE PAIN TRIAL

This was a multicenter, three arm, randomized to a control trial where the ability of amniotic suspension allograft to modulate inflammation and swelling was compared with saline and hyaluronic acid (HA) injections in patients with knee osteoarthritis. A new study conducted at New York’s Hospital for Special Surgery titled, “ A Randomized Controlled Single-Blind Study Demonstrating Superiority of Amniotic Suspension Allograft Injection Over Hyaluronic Acid and Saline Control for Modification of Knee Osteoarthritis Symptoms” published in the Journal of Knee Surgery found clear evidence that amniotic suspension allograft (ASA) injections may be a superior anti-inflammatory treatment for knee osteoarthritis.